Pack size
HiTrap™ chromatography columns with MabSelect™ VL protein L resin. A redesigned protein L ligand captures antibody Fabs, bispecifics, and other variants containing a kappa light chain with high binding capacity and improved alkaline stability.
As the diversity of antibody variants increases, so does the need for chromatography resins that can capture and purify these variants. As an alternative to protein A, protein L can be used to capture antibody Fabs, bispecific antibodies, and other molecules containing kappa variants of the variable light (VL) chain. Protein L binds human kappa light chain subtypes 1, 3, and 4 and mouse kappa light chain subtype 1.
We observed a two-fold increase in binding capacity of MabSelect™ VL resin compared to our Capto™ L chromatography resin and HiTrap™ Protein L columns. This higher capacity provides productivity advantages in research and biomanufacturing.
The MabSelect™ VL resin can withstand cleaning with 0.1 M NaOH, thanks to multimerization and modification of one of the domains of the native protein L ligand.
MabSelect™ VL protein L resin is also available as bulk resins in different pack sizes, PreDictor™ RoboColumn® minicolumns, ReadyToProcess™ columns. Contact your Cytiva sales representative for more information.
