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Evaluate binding sites


Affinity chromatography separates proteins based on a reversible binding interaction between the target protein and a ligand. Whether you’re purifying monoclonal antibodies or fragments such as Fabs or scFvs, knowing the binding site and structure of your target molecule is key to a successful purification. Click the figure to learn about protein A, protein L, and other affinity ligands.

Select capture resin

MabSelect™ VL has a strong affinity to the variable region of antibody kappa light chains.
MabSelect PrismA™ resin, MabSelect PrismA™ X resin, and Fibro PrismA fiber units bind to both the VH3 and Fc regions. MabSelect™ SuRe 70 resin binds only to the Fc region.
MabSelect™ VH3 resin binds only to the VH region of the VH3 sequence family.
MabSelect PrismA™ resin, MabSelect PrismA™ X resin, and Fibro PrismA fiber units bind to both the VH3 and Fc regions.
KappaSelect resin is designed for purification of human Fab (kappa) fragments. LambdaFabSelect resin binds to the constant region of the lambda light chain.
Bispecific antibody image, asymmetric