MabSelect SuRe™ LX resin prepacked in ReadyToProcess™ columns
These chromatography columns are prepacked with MabSelect SuRe™ LX protein A resin for capture of monoclonal antibodies (mAbs) at process scale. ReadyToProcess™ columns are validated high-performance bioprocessing columns that are supplied prepacked and ready to use.
MabSelect SuRe™ LX resin prepacked in ReadyToProcess™ columns
These chromatography columns are prepacked with MabSelect SuRe™ LX protein A resin for capture of monoclonal antibodies (mAbs) at process scale. ReadyToProcess™ columns are validated high-performance bioprocessing columns that are supplied prepacked and ready to use.
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Overview
These chromatography columns are prepacked with MabSelect SuRe™ LX protein A resin for capture of monoclonal antibodies (mAbs) at process scale. ReadyToProcess™ columns are validated high-performance bioprocessing columns that are supplied prepacked and ready to use.
- Alkaline-tolerant rProtein A ligand withstands rigorous cleaning and sanitization procedures with 0.1 to 0.5 M NaOH.
- High dynamic binding capacity for high-titer monoclonal antibody capture.
- Enables increased bioburden control.
MabSelect SuRe™ LX resin is a member of the MabSelect™ family of affinity resins for the capture of mAbs at process scale. MabSelect SuRe™ LX resin shares features and benefits of MabSelect SuRe™ resin such as an alkaline stabilized protein A ligand, rigid, high-flow agarose matrix that ensures excellent pressure/flow properties, a low non-specific binding that leads to low impurity levels in the eluate pool, and an oriented ligand coupling for optimized protein binding capacity.
The enhanced alkaline-stability and high capacity of MabSelect SuRe™ LX resin improves process economy and product quality; cleaning can be performed with cost-effective reagents such as sodium hydroxide, eliminating the need for expensive and hazardous cleaning agents such as Gua-HCl.
The protein ligand construct of MabSelect SuRe™ LX resin has been shown to have increased stability towards proteases. Therefore, the level of leakage of the MabSelect SuRe™ LX ligand during elution is low.
MabSelect SuRe™ resin has been demonstrated to give generic elution conditions for different monoclonal antibodies, which is an advantage when designing generic purification platform processes. This feature is also correlated toretained in the construction of the MabSelect SuRe™ LX ligand.
Key benefits of ReadyToProcess™ columns include:
- Robust column design and validated packing methods enable consistent column performance.
- Standardized column formats allow reduced column cost and shorter delivery lead times.
- Cost-savings by eliminating the need for column preparation, packing, and validation procedures.
- Fulfills industrial demands for security of supply, robust performance, and regulatory support.
Learn about MabSelect SuRe™ LX resin, prepacked HiScreen™ MabSelect SuRe™ LX columns, PreDictor™ MabSelect SuRe™ LX plates or PreDictor™ RoboColumns MabSelect SuRe™ LX minicolumns.
