Pall™ T-Series cassettes with Delta regenerated cellulose membranes
T-Series cassettes w/ Delta regenerated cellulose membranes, part of our Pall filtration portfolio, feature low protein binding membranes in the T-Series cassette for optimized process economics.
Pall™ T-Series cassettes with Delta regenerated cellulose membranes
T-Series cassettes w/ Delta regenerated cellulose membranes, part of our Pall filtration portfolio, feature low protein binding membranes in the T-Series cassette for optimized process economics.
1. Filtration area
2. MWCO
Overview
T-Series cassettes w/ Delta regenerated cellulose membranes, part of our Pall filtration portfolio, feature low protein binding membranes in the T-Series cassette for optimized process economics.
- Improved process performance. Cassettes are designed to provide optimal mass transfer to improve your process economics.
- Increased safety, reliability, and reproducibility. Superior new materials of construction are durable and stable and exhibit very low extractables.
- Easy scale-up for robust purification processes. Available in scalable formats with the same materials of construction from development to production-scale processes.
- High flux, high selectivity, and low protein binding are achieved with Delta regenerated cellulose membrane.
- Enhanced validation. T-series cassettes surpass the latest biopharmaceutical and regulatory standards such as biological reactivity, extractables, and TOC.
- The membrane is backpressure resistant up to 4.1 barg (60 psig).
Delta Regenerated Cellulose Membrane
Delta regenerated cellulose membrane offers high flux and selectivity. The cellulose membrane cassette has been specifically developed to minimize protein binding to the surface and interstitial structure of the membrane. Inherently hydrophilic, this membrane shows low protein adsorption properties and is optimal for processes involving very hydrophilic proteins. Delta regenerated cellulose membrane shows low fouling characteristics, allowing a constant performance or flux during a production run. It is easy to clean and typically recovers normalized water permeability (NWP) by using only 0.8N saline solution.
The T-Series Advantage
Superior new materials of construction and improved cassette design increase process safety, reliability, reproducibility, and productivity:
The feed and permeate screen material for T-Series cassettes is made from polypropylene which is highly resistant to sodium hydroxide.
Larger feed and permeate ports provide lower pressure drops.
T-Series cellulose membrane cassettes have been designed to provide maximum mass transfer through the membrane, resulting in faster processing times or reduced area installations compared to existing similar cassette formats.
Applications
T-Series cassettes with Delta regenerated cellulose membrane are designed for development, pilot, and production-scale TFF applications in diverse biological and biopharmaceutical processes. They are especially useful in:
- Antibody fragments (Fab)
- Purification and recovery of antibodies
- Concentration and diafiltration of recombinant proteins
- Blood plasma fractionation and purification
- Concentration and diafiltration of mRNA and saRNA
Product Platforms
T-Series Delta regenerated cellulose membrane cassettes complement our highly successful Centramate™ and Centrasette™ products and have been developed following years of experience designing and optimizing our customers’ biotech and biopharmaceutical processes.
Centramate™ T-Series cassettes for Centramate™ holders are offered in scalable membrane formats with effective filtration areas (EFA) from as low as 93 cm2 (0.1 ft2), making them ideal for process development and small-scale production of 50 mL to 125 L.
Centrasette™ T-Series cassettes, in combination with Centrasette™ holders, can process thousands of liters with installations incorporating hundreds of square meters of EFA
