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Oligonucleotide synthesis, purified for performance

Accelerate your oligo therapeutic to market with smart synthesis solutions and proven purification processes.

From rare to reliable, from niche to normal

Oligonucleotides are no longer reserved for rare genetic conditions, with more than half of clinical-stage oligo therapies now aiming to treat common diseases.

And larger patient populations call for robust, reliable workflows that deliver on demand.

With proven oligonucleotide synthesis platforms and comprehensive downstream solutions, we work with you to optimize your process and move your ASO or siRNA to market with confidence.

Your end-to-end oligo workflow

You want to deliver high‑quality oligonucleotides at the required scale, cost, and compliance level. You can achieve your goals with a complete, reliable workflow including:

Synthesize success at any scale

Worried about your dependence on CDMOs? Confidently take control of your oligonucleotide synthesis process by moving it in-house with:

Resources for when you're on the oliGO

Scalable oligonucleotide synthesis and purification

Find optimum purification conditions and maximize recovery using column chromatography.

Five essentials for accurate oligonucleotide chemistry

In this white paper, explore the key areas in your oligonucleotide chemistry where improvements will have a huge influence on the quality outcome of your synthesis.

Research-scale oligonucleotide workflow

View this infographic to see objectives, considerations, and strategies for each step of the oligo workflow.

Purification and quality control of an RNA 21-mer oligonucleotide

Review our recent poster outlining critical process parameters and key lessons learned for purifying native RNA.

Single-step purification of a 21-mer oligonucleotide

In this poster, we present a robust, fast, scalable, and simple purification protocol designed to meet the manufacturing demands of growing patient populations.

Solvent-free purification of D84-mer oligonucleotide

View our poster highlighting a single-use, solvent-free approach to downstream purification for longer oligonucleotides.

Power with the people

With more than four decades of experience and innovation in oligonucleotide manufacturing, we're prepared to help you speed up the time it takes to get your therapy to market no matter where you are in your process. From regulatory support to educational resources, we've got you covered.

A free, interactive course on oligonucleotide synthesis

Assistance with method development and optimization

Structured onboarding with system and software training

Early-run guidance for reproducible results

Regulatory support

Continuing support well after installation

Ready to intensify? Let's talk.

Whether you're facing capacity limits, high costs, or the pressure to move faster, we're here to help.

Our team understands you want a solution tailored to your needs.

Ready to intensify? Let's talk...

Frequently asked questions about oligo synthesis and purification

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