A scalable single-use, two-step plasmid purification process
Here we present a pDNA purification process using a 7.3 kb model plasmid.
Plasmid production
Bacterial plasmids are commonly engineered for research and industrial applications. In biomanufacturing, plasmid production includes robust plasmid purification steps to generate large quantities of highly pure supercoiled plasmid DNA (pDNA) for use as mRNA templates or in transient transfection of viral vectors.
Process development services
Use our know-how to simplify and accelerate your development and meet your process milestones.
Xcellerex™ XDR MO single-use stirred-tank fermentors
Single-use, stirred-tank fermentor systems for growing microbial cultures, in two sizes: 50 L and 200 L.
ÄKTA ready 450
Purify small quantity efficiently in a GMP environment.
Capto™ PlasmidSelect
Chromatography resin designed for purification of supercoiled DNA to high quality for gene therapy and DNA vaccine applications.
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Additional resources
- Viral vector tips
- Regulatory insights
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Related applications
- Cell therapy
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Other gene delivery
- AAV vector
- Adenovirus
- Lentivirus