This 16-layer construction is held constant from the laboratory-scale Mustang Q XT Acrodisc™ unit to the largest industrial process-scale capsule, ensuring constant chromatography bed depth in all formats. The ease of linear scale-up ensures a shortened process development time by significantly reducing the re-optimization required between scale-up steps. These chromatography products are specifically designed for single-use. This eliminates cleaning and the costs associated with cleaning validation. Mustang capsules are fully self-contained units that connect directly into a system using 18 mm (1.5 in.) sanitary flange connectors.

Mustang Q membrane

Mustang Q membrane is anion-exchange support with pendant quaternary amine functional groups in a cross-linked polymeric coating on a 0.8-micron pore-size membrane. This gives high dynamic capacities for high molecular weight products such as DNA, plasmids, or even particles as large as viruses.

Features and benefits

Binding efficiency: charged biomolecules are readily bound in a single pass
Speed: high-flow rates enable the processing of large volumes in less than a single working shift. Mustang units typically operate at flow rates between 10 to 40 membrane volumes per minute, making them much faster than conventional columns, which typically operate at 0.5 column volumes per minute.
Scalability: full range of sizes accommodates the different volumes and capacities required in biopharmaceutical processing
Convenience: Ready-to-use, autoclavable, and disposable to eliminate potential packing, cleaning, validation, and cross-contamination issues
Flexible: Available in capsule or cartridge format
Cost: lower operating costs and capital investment compared to conventional columns that need validated packing and cleaning

High-quality standards

Manufactured to high-quality assurance standards in accordance with ISO 9000
Membrane lots tested for dynamic protein binding capacity and peak position using standard proteins.
Identified by lot number and unique serial number for complete traceability of manufacturing history, satisfying stringent QC/QA requirements
Supplied with Certificate of Analysis to confirm quality control
Meets USP Biological reactivity tests in vivo in accordance with USP Class VI 50°C and all materials listed in Drug Master File submitted to the FDA

Comprehensive validation

Extensive validation to ensure consistent and reliable performance
A comprehensive validation guide is available for each of the membrane chemistries on request.