Capto L antibody fragment purification resin

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ID	Product Name
17547803	Capto L, 1 L
17547805	Capto L, 10 L
17547802	Capto L, 200 mL
17547801	Capto L, 25 mL
17547804	Capto L, 5 L
17547806	Capto L, 5 mL

Capto L resin is designed for antibody fragment purification, when the fragment contains the kappa light chain.

Suitable for the capture of a wide range of antibody fragments such as Fabs, dAbs, and single-chain fragment variable (scFv) .
High binding capacity, low ligand leakage, and selectivity for a broad range of antibody fragments reduces process time and amount of resin.
Enables a platform approach to antibody fragment purification.
Excellent productivity, process economy, and process design flexibility due to rigid matrix.
Hydrophilic base matrix ensures low levels of non-specific binding and low levels of host cell-derived impurities in the elution pool.
Fulfills industrial demands for security of supply, robust performance, and regulatory support.

Affinity resin for antibody fragment purification

Capto L combines a rigid, high-flow agarose matrix with the immunoglobulin-binding recombinant protein L ligand, which has a strong affinity to the variable region of antibody kappa light chains.

The high binding capacity and affinity to a broad range of antibody fragments makes this resin an excellent capture platform for antibody fragments containing kappa light chains. Common uses include domain antibody (dAb), scFv, and Fab purification.

Using this protein L resin

Capto L resin requires minimal optimization and produces high purity in one separation step, resulting in significant savings during process development. This resin is also advantageous in manufacturing, because high selectivity of affinity capture reduces the number of subsequent polishing steps.

Streamlined scale up

Scale-up with this resin is straightforward and is further aided by a range of prepacked process development tools, such as PreDictor plates, PreDictor RoboColumn™, and HiScreen prepacked columns.

Successful use in published research

Capto L is used in applications requiring the purification of antibody fragments through protein L affinity chromatography.

Compatible empty columns – research scale

Capto L resin is compatible with empty PD gravity flow, Tricorn, XK, and HiScale columns.

Compatible empty columns – bioprocess scale

For process-scale applications, Cytiva recommends AxiChrom columns.

Convenient prepacked columns – research scale

Capto L resin is available in the following formats:

HiTrap Protein L: convenient for easy use with a syringe, peristaltic pump, or chromatography system
HiScreen Capto L prepacked column, for method and process development
PreDictor Capto L 96-well plate, for high-throughput screening or process development

Convenient prepacked columns – bioprocess scale

Prepacked ReadyToProcess columns are available, eliminating the need for column packing and cleaning validation.

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Product	Product Name	Pack size All 5 mL 10 L 1 L 25 mL 5 L 200 mL	Price
17547805	Capto L, 10 L	10 L	On Request	Get Quote
17547803	Capto L, 1 L	1 L	14 125.00 USD	Add to cart Get Quote In Stock Stock on request Limited stock
17547801	Capto L, 25 mL	25 mL	1 002.00 USD	Add to cart Get Quote In Stock Stock on request Limited stock
17547802	Capto L, 200 mL	200 mL	4 010.00 USD	Add to cart Get Quote In Stock Stock on request Limited stock
17547804	Capto L, 5 L	5 L	On Request	Get Quote
17547806	Capto L, 5 mL	5 mL	624.00 USD	Add to cart Get Quote In Stock Stock on request Limited stock

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Capto L antibody fragment purification resin

Capto L antibody fragment purification resin

Affinity resin for antibody fragment purification

Using this protein L resin

Streamlined scale up

Successful use in published research

Compatible empty columns – research scale

Compatible empty columns – bioprocess scale

Convenient prepacked columns – research scale

Convenient prepacked columns – bioprocess scale

Select your model

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