The Allegro™ Connect Virus Filtration System is a single-use automated filtration system designed to deliver robust process control during this critical downstream step.
Integrated Palltronic™ Flowstar LGR filter integrity test instrument for in-situ pre-use and post-use integrity testing of virus filters as well as pre-use manifold leak test.
Configurable recipe-controlled phases to automatically perform pre-use system equilibration, product filtration and buffer chase, with maximum product recovery utilizing standard manifolds
Smooth transition between filtration and buffer chase phase while keeping the process parameter within the limit to eliminate impact on virus retention from back diffusion during process interruptions
Wide range of process options to control functions such as flow, differential pressure and inlet pressure, that covers the majority of virus filtration process strategies
Flexible configuration compatible with all commonly used virus filters
Easy to install single-use flow path with the shadow board concept and guided human machine interface (HMI) instructions for installation in less than 60 minutes and uninstallation in less than 15 minutes by a single operator
Batch reporting summary compiling data from the single-use sensors within the flow path, filter integrity testing results, and other critical process parameters.
This next generation compact and elegant system is designed to minimize risk through a fully automated process with recipe-controlled steps, including pre-use manifold leak test, pre-use and post-use filter integrity tests (with the help of an integrated Palltronic® Flowstar IV Filter Integrity Test Instrument), system priming, product filtration and buffer chase, with all data stored in a batch reporting system, significantly reducing non-conformities and manual labor.
The Allegro™ Connect virus filtration system utilizes single-use technology (SUT) to ensure faster turnaround between product batches, eliminating the need for clean-in-place (CIP) and sterilization-in-place (SIP) operations and associated cleaning validation, reducing maintenance costs and system downtime, thereby ensuring increased plant productivity.
The entire flow path has been designed for easy installation and removal, with clearly marked connections and a shadow board to visibly guide the user, reducing the risk of human error.The Allegro™ Connect virus filtration system has undergone extensive usability trials to ensure the system is simple and intuitive to use. Visual instructions for installation (IFI) have been created and are accessible via the HMI screen providing operators with a step-by-step guide to installing the single-use flow paths and making the relevant fluid connections.
This study demonstrates the effectiveness of the Allegro™ Connect virus filtration system in performing fully automated virus filtration, including in situ flow kit leak testing and filter integrity testing.
Training/education
Find online or in-person courses for the Allegro™ Connect virus filtration system in our e-learning center.
Video: Detailed overview/virtual demo of the Allegro™ Connect virus filtration system
Services
Equipment services:Cytiva's service solutions offer comprehensive, customizable support throughout your equipment’s lifecycle. Find a service agreement that meets your needs and desired outcome.
Our web-based Change Control Notification (CCN) service ensures that you are notified about changes that could potentially impact your product or process. Subscribe to CCNs on our Regulatory Support page.
