Sensor Chip Protein A
Biacore sensor chip for orientation-specific binding of antibodies (predominantly human) through Fc-region.
Sensor Chip Protein A
Biacore sensor chip for orientation-specific binding of antibodies (predominantly human) through Fc-region.
1. Sensor chip format
2. For use with
3. Pack size
Overview
- With MabSelect SuRe ligand on the surface.
- Site-directed capture of antibody: binds predominantly to the heavy chain within the Fc region and ensures antibodies are bound to the surface in a specific orientation.
- Time and effort savings: ready-to-use sensor chip eliminates the need to develop immobilization and regeneration conditions.
- Confidence in data: highly controlled development processes and manufacturing conditions ensure reproducible results.
Surface description
Carboxymethylated dextran matrix with a recombinant Protein A variant covalently attached. The surface ligand is the same as is used for our MabSelect SuRe protein purification products.
- Binds antibodies from several mammalian species, most notably human antibodies of the subclasses IgG1, IgG2, and IgG4.
- Binds only to the heavy chain within the Fc region, ensuring a specific orientation of the antibody on the surface.
- Does not bind Fab fragments (unlike native Protein A).
Sensor chip formats for Biacore systems
Biacore sensor chips are available in two formats.
Series S sensor chips are for use with Biacore 1 series, Biacore 8 series, Biacore S200, Biacore T200, and Biacore 4000 SPR systems.
Sensor chips not designated with series S are designed for Biacore X100, and Biacore C SPR systems.
Convenient antibody analysis in Biacore systems
Sensor Chip Protein A is a sensor surface pre-immobilized with a recombinant Protein A variant binding antibodies for protein interaction analysis using Biacore systems. It is ready-to-use with high binding capacity offering a wide dynamic range and high convenience, reproducibility, and robustness. Sensor Chip Protein A is an excellent surface choice for antibody quantitation and characterization in biopharmaceutical late stage development and manufacturing QC.
