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In-house manufacturing
Instead of waiting on a CMO, consider bringing vector production in-house. Reduce risk and optimize efficiency with flexible, modular manufacturing options and expert support.
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Scalable viral vector production
Speed and efficiency become critical as you scale up your process. End-to-end single-use solutions with integrated automation can help you get there – whether you’re at 10 L or 500 L scale.
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AAV workflow solutions
Your adeno-associated virus (AAV) gene therapy deserves to be a success. To get there, you’ll need a process that’s scalable and cost effective.
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Vaccine platforms
Gain insights to increase the opportunity to meet tomorrow’s vaccine manufacturing needs with innovative technologies and process strategies.
Emerging biotech solutions
Plasmids
Viral vectors
- News: Collaboration on viral vectors for preclinical research
- News: Collaboration with Children’s Medical Research Institute
- Blog: Tips for viral vector production
- Article: Lentiviral vector process development
- Article: Upstream lentiviral vector process
- Application data: End-to-end adenovirus process
- Article: Getting ahead of the game in cell and gene therapy
- Article: How to prepare for the future of viral vector manufacturing
Plasmids
- Xcellerex XDR microbial system – single-use, stirred-tank fermentor for growing plasmid-containing microbial cultures
- Capto PlasmidSelect resin and columns – to purify supercoiled plasmid DNA
Upstream viral vectors
- Xcellerex XDR platform – single-use, stirred-tank bioreactors for cell cultivation up to 2000 L
- ReadyToProcess WAVE 25 bioreactor – single-use, rocking bioreactor for growing cells up to 25 L
- HyClone media and reagents – for cell growth, transfection, and buffer preparation
- Cytodex microcarriers – for growing adherent cells in suspension culture
- Single-use bags and connectors – to make aseptic connections between single-use components
Downstream viral vectors
- Xcellerex mixers – single-use mixers for media and buffer preparation
- Single-use bags and connectors – to make aseptic connections between single-use components
- ULTA NFF filters – single-use capsules for harvest, clarification, and final filtration
- ReadyToProcess TFF filters – single-use cartridges for concentration
- ÄKTA tangential flow filtration systems – range of single-use filtration systems from benchtop to GMP production
- ÄKTA chromatography systems – range of automated systems from benchtop to GMP production
- Anion exchange resins and columns – for virus purification
- Capto Core 700 resin and columns – combines size exclusion and binding properties for virus purification
- Capto Core 400 resin and columns – for intermediate purification and polishing
- Capto AVB resin and columns – affinity purification of AAV, with ligand derived from single-chain antibody
- Heparin Sepharose – heparin-based affinity purification of AAV
- Size exclusion resins and columns – for virus purification and analysis