Small molecule drug discovery

White paper
  • White paper
  • Application Notes
  • Articles
  • Posters
Key SPR applications
  • Key SPR applications
  • Bioanalytics in drug development and QC
  • Biotherapeutic drug discovery
  • Protein interaction analysis
  • Small molecule drug discovery
  • Get started with SPR interaction analysis
  • Biacore SPR products
  • Biacore software downloads
  • Interaction analysis with Biacore SPR systems
  • Training courses

White Paper

  • Outstanding sensitivity for confident label-free interaction analysis

  • Biacore systems in small molecule discovery

Application Notes

  • Fragment library screening against the Hepatitis C drug target, NS5B 1b, in the search for novel allosteric drug leads

  • Characterizing lead compounds using label-free interaction analysis: Blocking T-cell activation in rheumatoid arthritis therapy

  • Profiling inhibitor selectivity for PARP protein family members

Articles

  • Reducing attrition early in discovery

  • Surface plasmon resonance (SPR): Three decades of SPR supporting target-based drug discovery

  • Transparent machine learning solution - SPR data evaluation

    Transparent machine learning – AI(d) to overcome inconsistencies in SPR data analysis ,saving time and increase productivity in LMW discovery

  • Characterizing PROTAC ternary complex formation using Biacore™ SPR systems

    We describe a simple and robust method to characterize the kinetics of target protein:PROTAC:ligase ternary complex formation.

Posters

  • Dual parameter screening — two for the price of one

    This poster demonstrate the principle using functionality in Biacore™ Insight Evaluation Software to extract antibody titer and kinetics from the same data set in a single run.