Oligonucleotide synthesis

The rapidly growing nucleic acid therapeutics field is enabled by advanced synthesis technology. Our portfolio includes DNA synthesis machines, RNA synthesis equipment, and oligo synthesis reagents to support precise, scalable production. From automated solid-phase synthesis systems to high-purity reagents, we deliver solutions that optimize yield, purity, and reproducibility for research and GMP workflows at a wide range of scales. Explore our oligonucleotide synthesis products today and accelerate your development pipeline.

Showing 1-14 of 14 items

Adjustable Oligo column

Adjustable Oligo column is our largest column for oligonucleotide synthesis, designed for process development with the ÄKTA oligopilot plus synthesizer. The column volume can be adjusted to the volume required, solid support used, and scale intended.

Adjustable Oligo Column

18110760

Stock on request

On request

ÄKTA oligopilot™ plus lab scale oligonucleotide synthesizer

ÄKTA oligopilot plus is a compact, pump-driven system for small-scale synthesis design in two different scale ranges: 10 – 50* μmol and 50 µmol – 9* mmol. It is a flexible, cost-efficient, and fully automated synthesizer employing flow-through synthesis technology. The instruments are designed for research and process development of oligonucleotide synthesis process.

ÄKTA oligopilot plus 10

18114042

Discontinued

ÄKTA oligopilot plus 100

18113679

Temporarily unavailable

ÄKTA oligosynt™ oligonucleotide synthesizer

The ÄKTA oligosynt™ oligonucleotide synthesizer is a compact, fully automated oligonucleotide synthesizer built for research and process development laboratories. The system supports a robust and easily scalable oligonucleotide synthesis process and transfer to larger oligonucleotide synthesizers with high yield and quality.

ÄKTA oligosynt synthesizer system

29628148

Stock on request

On request

AxiTide™ Columns

AxiTide™ is our most modern synthesis column that has a design based on our AxiChrom™ columns adapted with height of column tube, adaptor, and changes of materials to withstand the harsh chemicals used in oligonucleotide synthesis.

AxiTide 140 Synthesis column

29358080

Stock on request

On request

AxiTide 50 Synthesis column

29358075

Stock on request

On request

Cy3™ Amidite

CyDye fluors combine exceptional photostability with bright and intense signals, resulting in high sensitivity and a highly reproducible performance at a biologically suitable pH range of 3 to 10.

Amersham Cy3 Amidite, 1 g

28917299

Stock on request

4,811.00 USD

Amersham Cy3 Amidite, 100 mg

28917298

Stock on request

552.00 USD

Cy5.5™ Amidite

TempliPhi™ Sequence Resolver Kit resolves most of the sequencing stops or gaps that routinely elude other commonly used finishing methods. The use of this kit eliminates the need to use dGTP chemistry, which can affect the accuracy of a sequence due to the appearance of sequence compression. In addition, it eliminates the need for additives in the sequencing reaction.

Amersham Cy5.5 Amidite, 1 mg

28902160

In stock–11 available

5,190.00 USD

Amersham Cy5.5 Amidite, 100 mg

28904250

Stock on request

838.00 USD

Cy5™ Amidite

CyDye fluors combine exceptional photostability with bright and intense signals, resulting in high sensitivity and a highly reproducible performance at a biologically suitable pH range of 3 to 10.

Amersham Cy5 Amidite, 1 g

28902158

Selling fast–2 available

4,672.00 USD

Amersham Cy5 Amidite, 10 g

28904298

In stock–8 available

33,100.00 USD

Amersham Cy5 Amidite, 100 mg

28904249

In stock–10 available

598.00 USD

FineLINE™ 35 Oligo column

FineLINE™ 35 Oligo column is designed for oligonucleotide synthesis and it is suitable for use with ÄKTA oligosynt™ synthesizer. It is capable of withstanding the harsh organic conditions in oligonucleotide synthesis.

FineLINE 35 oligo Column

28946841

In stock–8 available

7,629.00 USD

OligoPilot™ 400 oligonucleotide synthesizer

OligoPilot 400 is designed to produce hundreds of grams oligonucleotides for early to mid-clinical trials, covering a range of 4 to 60 mmol. With the speed of coupling, one lot can easily be produced per day. Maintaining well-trained staff, using efficient standard operating procedures (SOPs) and secure supply it can be part of a manufacturing train producing in the range of >50 kg/year. Using shifts the capacity can be multiplied.

OligoPilot 400

28989965

Temporarily unavailable

OligoPilot™ oligonucleotide synthesizer

Synthesize oligonucleotides at scales of 10–150 mmol for early to mid-phase clinical trials or for diagnostic kits. This robust system has a footprint small enough to fit in a walk-in fume hood. Scale up easily with common UNICORN™ control software.

OligoPilot

29706681

Stock on request

On request

OligoProcess™ oligonucleotide synthesizer

OligoProcess covers a range of 10 to 1800 mmol and is suitable for quantities required in clinical phases and commercial production. Its broad scale and verified components enable it to produce hundreds of kilos, or even metric tons, of oligonucleotides every year.

OligoProcess

29589047

Stock on request

On request

Primer Support™ 5G for DNA and RNA Synthesis

Primer Support™ 5G products are the fifth generation solid supports for oligonucleotide synthesis from Cytiva.These high-loaded solid support products are optimized for synthesis of oligonucleotides with a length of up to 70 nucleotides.

Primer Support 5G, amino, 10 g

29099992

Stock on request

280.00 USD

Primer Support 5G, amino, 50 g

29025961

Stock on request

1,225.00 USD

Primer Support 5G, amino, 500 g

29100343

Stock on request

9,251.00 USD

Primer Support 5G, dA 350, 1 mmol

28996425

Selling fast–5 available

109.83 USD

Primer Support 5G, dA 350, 10 mmol

28996430

Stock on request

859.00 USD

Primer Support 5G, dA 350, 100 mmol

29014613

Stock on request

8,590.00 USD

Primer Support 5G dC 350 1 mmol

28996426

Selling fast–5 available

109.83 USD

Primer Support 5G, dC 350, 10 mmol

28996431

Stock on request

859.00 USD

Primer Support 5G, dC 350, 100 mmol

29014614

Stock on request

8,590.00 USD

Primer Support 5G, dG 350, 1 mmol

28996427

Selling fast–5 available

109.83 USD

Small stainless steel columns

The small scale stainless steel columns are designed as fixed volume column reactors (complete incl. filters and sealings) and intended for oligonucleotide synthesis.

Column Reactor 1.2 ml

18110110

Selling fast–4 available

1,159.00 USD

Column Reactor 12 ml

18110116

Selling fast–2 available

1,512.00 USD

Column Reactor 24 ml

18110119

Stock on request

1,650.00 USD

UNICORN™ 7 control software

UNICORN™ control software is a scalable software supporting systems from small-scale research through clinical- and full-scale manufacturing.

UNICORN 7 Academia

29708933

Stock on request

On request

UNICORN 7 Column logbook lic

29702892

Stock on request

1,518.00 USD

UNICORN 7 Dry

29702884

Stock on request

760.00 USD

UNICORN 7 Evaluation Classic

29702888

Stock on request

303.00 USD

UNICORN 7 Filtration/Wave

29708936

Stock on request

On request

UNICORN 7 Manufacturing

29708935

Stock on request

On request

UNICORN 7 Remote

29702882

Stock on request

1,518.00 USD

UNICORN 7 StdAlon Evaluation

29702886

Stock on request

455.00 USD

UNICORN 7 workstation license for ÄKTA avant (for UNICORN 7.13 and later versions)

29879752

Stock on request

6,445.00 USD

UNICORN 7 WrkStn pure-BP-exp

29702890

Stock on request

3,796.00 USD

Showing 1-14 of 14 items

Frequently asked questions

Are your oligonucleotide synthesis products compatible with automated synthesizers?

Yes, our phosphoramidites and reagents are optimized for major synthesis platforms. They support high coupling efficiency and consistent yields.

How should phosphoramidites be stored for maximum stability?

Store phosphoramidites in a dry, inert atmosphere at recommended temperatures. Proper storage prevents degradation and ensures reliable synthesis.

What quality standards do your oligonucleotide synthesis products meet?

Our products comply with stringent quality controls and documentation to support regulated environments. Certificates of analysis are available for all items.

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Oligonucleotide synthesis

Frequently asked questions